Overview:
The Neuro lab at BILSAB, directed by Dr. Mustafa Aziz Hatiboglu, has a wide array of interests in glioma and brain metastasis. Specifically, the lab is interested in glioma cancer stem cells and investigates their relation with tumor microenvironment, and their immune evasion mechanisms. They are also seeking possible bio-marker candidates via liquid biopsy (cellular free DNA, exosomes, and miRNAs), which can be used for diagnosis and surveillance. In addition, Neuro lab has projects on mouse glioma models, tumor microbiome, chemo- and radio-resistance mechanisms, glioma pathogenesis, combinational therapies, and radiogenomics.
Publications (selected):
- Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3. Hatiboglu MA, Kocyigit A, Guler EM, Akdur K, Khan I, Nalli A, Karatas E, Tuzgen S. World Neurosurg. 2019 May 2. pii: S1878-8750(19)31201- doi: 10.1016/j.wneu.2019.04.205.
- Can COVID-19 induce glioma tumorogenesis through binding cell receptors? Khan, I., Hatiboglu, M.A.* Med Hypotheses, 2020 June 19; 144: 110009 [*Corresponding author].
- Herbal Medicine for Glioblastoma: Current and Future Prospects. Khan, I., Mahfooz, S., & Hatiboglu, M. A.* Med Chem. 2020 Jan 29. doi: 10.2174/1573406416666200130100833. [*Corresponding author].
- Targeting Glioblastoma: The Current State of Different Therapeutic Approaches. Khan, I., Mahfooz, S., Elbasan, E. B., Karacam, B., Oztanir, M. N., & Hatiboglu, M. A.* Curr Neuropharmacol, 2021 Jan 13. [*Corresponding author].
- Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma. Khan, I., Baig, M. H., Mahfooz, S., Rahim, M., Karacam, B., Elbasan, E. B., ... & Hatiboglu, M. A.* Int J Mol Sci., 2021 Jan 28;22(3):1318. [*Corresponding author].
Grants (Ongoing):
| 2019- 2022 | Title: International Evaluation of genetic, proteomic and metabolomics properties in Turkish patients with brain tumors Sponsor: Turkey Institutes of Health Presidency Total direct cost: 95.000 TL Role: Principal investigator |
Projects:
- Identification of resistance mechanisms in glioma cancer stem cells.
- Investigating the relation between glioma cancer stem cell and immune properties in tumor microenvironment.
- Investigating the molecular mechanism of NOTCH signaling in chemoresistant glioblastoma cell line model system.
- Isolation of 'circulating tumor cells' and 'cell free DNA' from peripheral blood and cerebrospinal fluid in patients with glial tumors: Assessing their effect on the prognosis.
- Liquid biopsy in CNS lymphoma: Role of miRNAs, cf-DNA and exosomes in diagnosis and prognosis.
- Investigating possible inhibitors against Factor H in relation to glioblastoma.
- Microbiome in glioma.
- Identifying diagnostic bio-markers via Liquid biopsy in meningioma.
Teaching:
Graduate Courses
Title: Translational research in Neurooncology.
Programme: Doctorate in Philosophy (PhD)
Location: Bezmialem Vakif University, Turkey
Title: Management of brain metastasis.
Programme: Neurosurgery residency program
Location: Bezmialem Vakif University, Turkey
Graduate Student Supervision
- PhD, Büşra Karaçam, Istanbul University, DETAM. 2020 – Present.
- PhD, Berrin Saraçoğlu, Bezialem Vakif University. 2020 – Present.
- Neurosurgery speciality thesis, Güven Gönen, Bezialem Vakif University. 2017 – Present. Investigating the role of various radiation dosing schema on systemic and local immune response using Gamma Knife radiosurgery in established intracerebral glioma mouse model
- Neurosurgery speciality thesis, Sadık Tokar, Bezialem Vakif University. 2017 – Present.
Lab Research Team:
Mustafa Aziz Hatiboglu, MD: Principal Investigator
Büşra Karaçam: Research Assistant
Öykü Dağdeviren: Technician
Contact Info:
E-mail: bilsab.neuro@gmail.com
