Menü Kuruluş TarihçesiMerkezin AmacıYönetim Kurulu ÜyeleriKurucu EkipAraştırma HizmetleriProje İştirakçileriMisyon ve VizyonGETAMER EkibiProjelerimizYayınlarımızFaaliyetlerimizOrganizasyon Şeması Yayınlarımız Yenigun, V. B., Kocyigit, A., Gul, A. Z., Balkan, E., & Kanımdan, E. (2025). Copper (II)‐Enhanced Cytotoxic Effects of Inula viscosa Against Colon Cancer. ChemistrySelect, 10(37), e03005.Yenigun, V. B., Kanimdan, E., & Kocyigit, A. (2025). In Vitro Evaluation of a Herbal Oil Combination: a Potential Phytopharmaceutical Targeting TMPRSS2, Furin, and ACE2 in SARS‐COV‐2 Infection. ChemistrySelect, 10(16), e202500256.Yenigun, V.B.,, Guler, E. M., Kocyigit, A., Ökten, S., Balkan, E., & Çakmak, O. (2025). Cytotoxic, Genotoxic, Apoptotic, and Reactive Oxygen Generating Properties of Bioactive Quinoline Derivatives as Novel Anti Breast Cancer Agents. Cell Biochemistry and Biophysics, 1-15.Guler, E. M., Bozali, K., Huseyinbas, O., Celikten, M., & Kocyigit, A. (2025). Combination of 5‐Fluorouracil and Thymoquinone for Enhanced Cytotoxicity, Genotoxicity and Apoptosis In Colorectal Cancer: In Vitro and In Vivo Studies. Journal of Biochemical and Molecular Toxicology, 39(5), e70276.Durdu, B., Durdu, Y., Guler, E. M., Kocyigit, A., & Okay, G. (2025). Comparative effects of dexpanthenol and thymoquinone on colistin-induced neurotoxicity in rats. Naunyn-Schmiedeberg's Archives of Pharmacology, 398(7), 8391-8398.Yenigun, V.B., Kocyigit, A., Kanimdan, E., Balkan, E. and Gul, A.Z., (2024). Copper (II) increases anti-Proliferative activity of thymoquinone in colon cancer cells by increasing genotoxic, apoptotic, and reactive oxygen species generating effects. Toxicon, 250, p.108103.Kocyigit, A., Kanimdan, E., Yenigun, V.B., Ozman, Z., Balıbey, F.B., Durmuş, E. and Yasar, O., (2024). Olive Leaf Extract Downregulates the Protein Expression of Key SARS‐CoV‐2 Entry Enzyme ACE‐2, TMPRSS2, and Furin. Chemistry & Biodiversity, p.e202400717.Bozali, K., Metin Guler, E., & Kocyigit, A. (2024). A Study on Thymoquinone: Antioxidant Capacity and Anticancer Activities in LoVo Colorectal Cancer Cells. Chemistry & Biodiversity, 21(2), e202301886.Kara, M., Sahin, S., Rabbani, F., Oztas, E., Hasbal-Celikok, G., Kanımdan, E., ... & Khan, A. (2024). An in vitro analysis of an innovative standardized phospholipid carrier-based Melissa officinalis L. extract as a potential neuromodulator for emotional distress and related conditions. Frontiers in Molecular Biosciences, 11, 1359177.Durmus, E., Ozman, Z., Ceyran, I. H., Pasin, O., & Kocyigit, A. (2024). Chrysin Enhances Anti‐Cancer Activity of Jurkat T Cell and NK‐92 Cells Against Human Breast Cancer Cell Lines. Chemistry & biodiversity, 21(10), e202400806.Öter, G. N., Durmuş, E., Şen, A., & Koçyiğit, A. (2024). Induction of Apoptosis through Oxidative Stress Caused by Rubus tereticaulis Leaves Extracts in A549 Cells. European Journal of Biology, 83(1), 50-59.Cintesun, S., Ozman, Z., Kocyigit, A., Mansuroglu, B., & Kocacaliskan, I. (2023). Effects of walnut (Juglans regia L.) kernel extract and juglone on dopamine levels and oxidative stress in rats. Food Bioscience, 51, 102327.Türkdoğan, M. K., Koçyiğit, A., Güler, E. M., Özer, Ö. F., Demir, K., & Uğur, H. (2023). Oleuropein exhibits anticarcinogen effects against gastric cancer cell lines. Molecular Biology Reports, 50(11), 9099-9105.Balıbey, F. B., Bahadori, F., Ergin Kizilcay, G., Tekin, A., Kanimdan, E., & Kocyigit, A. (2023). Optimization of PLGA-DSPE hybrid nano-micelles with enhanced hydrophobic capacity for curcumin delivery. Pharmaceutical Development and Technology, 28(9), 843-855.Kocyigit, A., Guler, E. M., Durmus, E., Yenigun, V. B., Kanimdan, E., Ozman, Z., ... & Aydogdu, G. (2023). Propolis Enhances 5‐Fluorouracil Mediated Antitumor Efficacy and Reduces Side Effects in Colorectal Cancer: An in Vitro and in Vivo Study. Chemistry & Biodiversity, 20(9), e202300591.Betul Yenigun, V., Acar, H., Kanimdan, E., Yenigun, A., Kocyigit, A., & Cora, T. (2023). KRAS Mutation Reduces Thymoquinone Anticancer Effects on Viability of Cells and Apoptosis. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 23(15), 1747-1753.Emre, Ş. A. M., Mithat, E. K. Ş. İ., Akkaş, F., BAYTEKİN, H., Güler, E. M., ŞİMŞEK, A., ... & TAŞÇI, A. İ. The Effects of Viburnum Opulus L. on Kidneys of Rats with Ethylene Glycol-induced Nephrolithiasis. The New Journal of Urology, 18(3), 216-229.Yenigün, V. B., Kocyigit, A., Kanımdan, E., Durmus, E., & Koktasoglu, F. (2023). Hedera helix (Wall Ivy) leaf ethanol extract shows cytotoxic and apoptotic effects in glioblastoma cells by generating reactive oxygen species. Acta Medica, 54(4), 295-303.Öter, G. N., Durmuş, E., Şen, A., & Koçyiğit, A. (2023). Induction Of Apoptotic Cell Death In Human Lung Cancer Cells Through Enhanced Oxidative Stress Caused By Rubus Tereticaulis Leaves Extracts. Turkish Journal of Biochemistry/Turk Biyokimya Dergisi, 48.Gungor, A. S., Durmus, E., Kurt, B. Z., Kocyigit, A., Dalkilic, E., & Arisu, H. D. (2023). Effects of bioactive pulp-capping materials on cell viability, differentiation, and mineralization behaviors of human dental pulp stem cells In vitro. Operative dentistry, 48(3), 317-328.Gunes-Bayir, A., Guler, E. M., Bilgin, M. G., Ergun, I. S., Kocyigit, A., & Dadak, A. (2022). Anti-inflammatory and antioxidant effects of carvacrol on N-methyl-N′-nitro-N-Nitrosoguanidine (MNNG) induced gastric carcinogenesis in Wistar rats. Nutrients, 14(14), 2848.Yilmaz, A., Uckaya, F., Bayindir, N., Guler, E. M., Toprak, A., Kocyigit, A., ... & Topcu, G. (2022). Comparing healing effect against ulcerative colitis and toxicological effects of Rosmarinus officinalis: A comprehensive in vivo study of an edible plant in rats. Journal of Food Biochemistry, 46(11), e14299.Eskandari, Z., Bahadori, F., Yenigun, V. B., Demiray, M., Eroğlu, M. S., Kocyigit, A., & Oner, E. T. (2021). Levan enhanced the NF-κB suppression activity of an oral nano PLGA-curcumin formulation in breast cancer treatment. International Journal of Biological Macromolecules, 189, 223-231.Eskandari, Z., Bahadori, F., Yapaoz, M. A., Yenigun, V. B., Celikten, M., Kocyigit, A., & Onyuksel, H. (2021). Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles. European Journal of Pharmaceutical Sciences, 162, 105830.Kocyigit, A., & Guler, E. M. (2021). Antioxidant/pro-oxidant, anti-inflammatory, and immunomodulatory effects of thymoquinone in cancer prevention and treatment. In Handbook of oxidative stress in cancer: Therapeutic Aspects (pp. 1-14). Singapore: Springer Singapore.Bulut, H., Durmuş, E., Hacıosmanoğlu, E., Bozali, K., Şentürk, H., & Koçyiğit, A. (2021). Cuscuta campestris tedavisi ile mide kanseri hücrelerinde apoptozun indüklenmesi ve reaktif oksijen türlerinin oluşumu yoluyla proliferasyonun engellenmesi. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi, 54(2), 271-280.
