Mehmet Z. Doymaz, PhD (ABMM)
Lab Profile
Overview:
Our laboratory primarily investigates the immunological properties of proteins of Crimean-Congo Hemorrhagic Fever Virus. This virus gained an endemic status in this country and in many countries spanning from China to Kosova where the third of the world population inhabits. Complex life cycle of the virus involving ticks, wild rodents and domestic animals makes the preventive measures almost futile. Consequently, an immunological intervention to the disease and to its agent seem like the most effective mean to curb the spread of infection in the long haul. We are studying both humoral and cellular immune elements against the viral proteins, primarily nucleocapsid and glycoproteins with the forecast that a better understanding of the immunology and immunopathology of the infection will enable us to design better mechanisms to intervene the infectious process. Our laboratory set up is a typical immunology-molecular biology laboratory equipped with the state of the art means including confocal microscopy, FACS and protein purification instrumentations. The availability of animal facilities and other necessary core facilities makes us to address the immunological questions in in vivo conditions.
Affiliations:
-
Department of Microbiology, Medical School, Bezmialem Vakıf University
-
Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakıf University,
Education:
2001-2004
Clin. Fellowship, University of California, Los Angeles
1991-1992
Post-Doc, Mount Sinai School of Medicine, New York
1988-1991
PhD, University of Tennessee
1985-1988
MSc, University of Tennessee
1978-1983
DVM, Ankara University
Research Interests:
Viral Immunology, viral diagnostics, clinical microbiology, antibiotic resistant bacterial isolates,
Publications (selected):
-
Kalkan-Yazıcı M, Karaaslan E, Çetin NS, Hasanoğlu S, Güney F, Zeybek Ü, Doymaz MZ. 2021. Cross-Reactive anti-Nucleocapsid Protein Immunity against Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus in Multiple Species. J Virol. 2021 Jan 13:JVI.02156-20. doi: 10.1128/JVI.02156-20. Online ahead of print.
-
KalkanYazıcı, M., Koc, M. M., Cetin, N. S., Karaaslan, E., Okay, G., Durdu, B., Sumbul, B., Doymaz, M. Z., 2020. Discordance between serum neutralizing antibody (NAb) titers and the recovery from Coronavirus Disease-2019 (COVID-19). J. Immun. 2020 Sep 25:ji2000840. doi: 10.4049/jimmunol.2000840.
-
Sumbul B, Doymaz MZ. A Current Microbiological Picture of Mycobacterium Isolates from Istanbul, Turkey. Pol J Microbiol. 2020;69(2):1-7. doi: 10.33073/pjm-2020-021.
-
Doymaz MZ, Karaaslan E. 2019. Comparison of antibacterial activities of polymyxin B and colistin against multidrug resistant Gram negative bacteria. Infect Dis (Lond). 2019 Sep;51(9):676-682. doi: 10.1080/23744235.
Research Grants by:
Turkish Ministry of Development; Scientific and Technological Research Council of Turkey (TUBITAK); Turkish Institutes of Health (TUSEB); Bezmialem Vakıf University Scientific Research Project Unit,
Contact Info:
E-mail: mzdoymaz@bezmialem.edu.tr
