Menü Mehmet Ziya DoymazGülaçtı TopçuSerdar UysalAhmed S. AlyA. Matteen RafiqiOsman AkçakırMustafa Aziz Hatiboğlu Hatiboglu lab focuses research on investigating the mechanisms of brain tumors, establishing new effective treatments and finding new diagnostic and prognostic biomarkers. Their interest is on mainly malignant brain tumors such as glioblastoma and brain metastasis. For these purposes, they establish tumor bank and collect samples including fresh tumor tissue, serum and peripheral blood mononuclear cell samples from patients undergoing surgery for brain tumors. More than 250 patients' samples have been already collected and cryo-preserved so far.They isolate glioma cancer stem cells (GCSCs) and immune cells from fresh tumor tissue and look for chemo- and radio-resistance mechanisms. Also, they research the mechanism of immune response in tumor microenvironment and look at tumor infiltrating lymphocytes (TILs) and investigate specific signaling pathways along with GCSC in terms of immune system regulation. They also investigate the optimal radiation dosing schedule for brain tumors and combinational treatments in patients with glioma and brain metastasis treated with gamma knife radiosurgery, a type of radiation treatment. They are now doing 'liquid biopsy' to identify the role of cell free DNA, exosomes and micro-RNAs in glioma and brain metastasis patients for prognostic evaluation and assessing treatment response. Recently, they received the grant for evaluating genetic, proteomic and metabolomics properties in Turkish patients with brain tumors under 'Turkish Genomic Project'. Lab MembersPost-Doctoral FellowsImran Khan, PhDSadaf Mahfooz , PhDResearch AssistantBüşra Karaçam, MScResearcherElif Burçe ElbasanBerrin Saraçoğlu, PhD studentVolunteer Berre Toroman (Medical Student) Selected publications:Terzioglu-Usak, S., Nalli, A., Elibol, B., Ozek, E., & Hatiboglu, M. A. (2020). AnvirzelTM regulates cell death through inhibiting GSK-3 activity in human U87 glioma cells. Neurological Research, 42(1), 68-75. Khan, I., Mahfooz, S., & Hatiboglu, M. A. (2020). Herbal Medicine for Glioblastoma: Current and Future Prospects. Medicinal Chemistry. Khan, I., & Hatiboglu, M. A. (2020). Can COVID-19 induce glioma tumorogenesis through binding cell receptors?. Medical hypotheses, 144, 110009. Sinclair, G., Stenman, M., Benmakhlouf, H., Johnstone, P., Wersäll, P., Lindskog, M., Hatiboglu, M. A. & Harmenberg, U. (2020). Adaptive radiosurgery based on two simultaneous dose prescriptions in the management of large renal cell carcinoma brain metastases in critical areas: Towards customization. Surgical Neurology International, 11. Hatiboglu, M. A., & Sinclair, G. (2020). Coronavirus pandemic: how is neurosurgical-oncology practice affected?. British Journal of Neurosurgery, 1-3.Stenman, M., Benmakhlouf, H., Wersäll, P., Johnstone, P., Hatiboglu, M. A., Mayer-da-Silva, J., & Sinclair, G. (2020). Metastatic renal cell carcinoma to the brain: optimizing patient selection for gamma knife radiosurgery. Acta Neurochirurgica, 1-10. Sinclair, G., Johnstone, P., & Hatiboglu, M. A. (2020). Considerations for future novel human-infecting coronavirus outbreaks. Surgical Neurology International, 11. Hatiboglu, M. A., Kocyigit, A., Guler, E. M., Akdur, K., Khan, I., Nalli, A. & Tuzgen, S. (2019). Thymoquinone enhances the effect of gamma knife in B16-F10 melanoma through inhibition of phosphorylated STAT3. World neurosurgery, 128, e570-e581.Hatiboglu, M. A., Kocyigit, A., Guler, E. M., Akdur, K., Nalli, A., Karatas, E., & Tuzgen, S. (2018). Thymoquinone induces apoptosis in B16-F10 melanoma cell through inhibition of p-STAT3 and inhibits tumor growth in a murine intracerebral melanoma model. World neurosurgery, 114, e182-e190. Hatiboglu, M. A., Kong, L. Y., Wei, J., Wang, Y., McEnery, K. A., Fuller, G. N. & Heimberger, A. B. (2012). The tumor microenvironment expression of p‐STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. International journal of cancer, 131(1), 8-17.Dziurzynski, K., Wei, J., Qiao, W., Hatiboglu, M. A., Kong, L. Y., Wu, A. & Rao, G. (2011). Glioma-associated cytomegalovirus mediates subversion of the monocyte lineage to a tumor propagating phenotype. Clinical Cancer Research, 17(14), 4642-4649. Hatiboglu, M. A., Wei, J., Wu, A. S. G., & Heimberger, A. B. (2010). Immune therapeutic targeting of glioma cancer stem cells. Targeted oncology, 5(3), 217-227. Selected Congress AbstractsGliyal tümörlü hastalarda moleküler düzeyde HHV6/8, mikroRNA ve sitokinlerin varlığının incelenmesi ve prognoza etkisinin araştırılması (2020). Büşra Karaçam, Elif Burçe Elbasan, İmran Khan, Sadaf Mahfooz, Sadık Tokar, Ganime Çoban, Kerime Akdur, Ayten Şakarcan, Mustafa Namık Öztanır, Mehmet Ziya Doymaz, Mustafa Aziz Hatiboğlu. 14. Ulusal Tıbbi Genetik Kongresi.Hipofraksiyon Gamma Knife radyocerrahinin nüks gliyal tümörlerde miR-17 ve miR-124 aracılığı ile anti-tümör etkisinin gösterilmesi (2020) (Poster). Mustafa Aziz Hatiboğlu, Imran Khan, Kerime Akdur, Elif Burçe Elbasan, Büşra Karaçam, Yusuf Cicek, Sadaf Mahfooz, Ayten Sakarcan, Güven, Engin, Fahri Akbas. 34. Türk Nöroşirürji Derneği Bilimsel Kongresi.Likit Biyopsi ile Glial Tümörlü Hastalarda Kanda Serberst Bulunan DNA'nın Gösterilmesi (2020) (Poster), Mustafa Aziz Hatiboğlu, Büşra Karaçam, Elif Burçe Elbasan, Kerime Akdur, Sadaf Mahfooz, Ayten Şakarcan, Sadık Tokar, Güven Gönen, Engin Can, Imran Khan. 34. Türk Nöroşirürji Derneği Bilimsel Kongresi.Expressions of Immune-Related Tumor Suppressor MicroRNAs in Glioma Patients Undergoing Hypo-Fractionated Radiotherapy (2019). Imran Khan, Arife Nalli, Kerime Akdur, Yusuf Cicek, Sadaf Mahfooz, Ayten Sakarcan, Fahri Akbas, Mustafa Aziz Hatiboglu. The Immuno-Oncology 2019 World Congress, Barcelona, Spain. Thymoquinone enhances the sensitivity of B16-F10 melanoma cell line to Gamma Knife radiosurgery (2019). Mustafa Aziz Hatiboglu, Abdurrahim Kocyigit, Eray Metin Guler, Kerime Akdur, Imran Khan, Arife Nalli, Ersin Karatas, and Saffet Tuzgen. 14th Meeting of the European Association of Neuro-Oncology (EANO 2019) Lyon, France.