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Professor, Mustafa Aziz Hatiboğlu, M.D. ​

Lab Profile​

Overview:

Dr. Hatiboglu is interested in translational research particularly for glioma and brain metastasis, with the goal of taking research from bench-to-bedside. He studies the radio- and chemo-resistance mechanisms in brain tumors, establishing effective combinational treatments, glioma cancer stem cells, targeted therapies, liquid biopsy, and radiogenomics. He, as a neurosurgeon, is particularly performing surgeries for brain tumors using advanced techniques, such as awake craniotomy, intraoperative neuromonitoring and neuro-navigation. He is also director of the Gamma Knife Unit, and treats some of the brain tumors using Gamma Knife radiosurgery without requiring a surgical intervention. He has established a biobank, which includes more than 250 patients' tumor and blood specimens. Dr. Hatiboglu has international network particularly on oncology and radiation treatment research. He has published more than 65 international peer-reviewed research/review articles, book chapters, editorials, and has given numerous oral and poster presentations at national and international meetings.     

Affiliations:

1. Department of Neurosurgery, Bezmialem Vakif University Medical School, Turkey 

2. Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Turkey 

Education: 

Research Interests:

Glioma, brain metastasis, glioma cancer stem cell, immune regulation, chemo- and radio-resistance mechanisms in brain cancers, tumor microenvironment, radiation dose optimization, combinational treatments, liquid biopsy, radiogenomics, and brain cancer microbiome. 

Awards / Honors:

1. “Impact of Surgery on the Leptomeningeal Dissemination (LMD) of Supratentorial Brain Metastases (SBM)". Journal of Neuro-Oncology Award for 2008 AANS Meeting.  

2. “Evolution of Neurosurgical Treatment for Brain Metastases over the Last 15 Years: Experience at a Large Referral Cancer Center". National Brain Tumor Society Mahaley Clinical Research Award for 2010 CNS Meeting in San Francisco.  

Publications (selected)

1.  Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma. Khan, I., Baig, M. H., Mahfooz, S., Rahim, M., Karacam, B., Elbasan, E. B., ... & Hatiboglu, M. A. Int J Mol Sci., 2021 HJan 28;22(3):1318. doi: 10.3390/ijms22031318.
2. Khan, I., Mahfooz, S., Karacam, B., Elbasan, E. B., Akdur, K., Karimi, H., ... & Hatiboglu, M. A. (2022). Glioma cancer stem cells modulating the local tumor immune environment. Frontiers in Molecular Neuroscience, 15.
3. Khan, I., Baig, M. H., Mahfooz, S., Imran, M. A., Khan, M. I., Dong, J. J., ... & Hatiboglu, M. A. (2022, June). Nanomedicine for glioblastoma: Progress and future prospects. In Seminars in Cancer Biology. Academic Press.
4. Khan, I., . Isik, E.B., Mahfooz, S., Khan, M.A.,* & Hatiboglu, M. A,* 'Identification of Genetic Alterations in Rapid Progressive Glioblastoma by Use of Whole Exome Sequencing', Diagnostics (2023)
5. Khan I, Akdur K, Mahfooz S, Elbasan EB, Sakarcan A, Karacam B, Sinclair G, Selek S, Akbas F, Hatiboglu MA. Gamma Knife Radiosurgery Modulates micro-RNA Levels in Patients with Brain Metastasis. Curr Radiopharm. 2023 Feb 2. doi: 10.2174/1874471016666230202164557

Outlink (GScholar and AVESIS IDs):  

https://scholar.google.com.sg/citations?hl=en&user=BLPCA28AAAAJ 

https://avesis.bezmialem.edu.tr/mhatiboglu 

Grants (Ongoing) :

1. Glioblastoma'da Lipozomal mRNA Aşı Tedavisi: Mezenkimal Kök Hücreleri Aracılığı İle Anti-Tümör Ripk-3 mRNA Yüklü Lipozomların Taşınması (TUBITAK 2544)
2.  NOTCH1 genini hedef alan teröpatik mikroRNA'ların Temozolomide dirençli glioblastoma hücre hattında araştırılması (BAP)
3. Beyin tümörlerinin metabolik profillerinin incelenmesi (BAP)
4. Gliomalı Hastalarda Tümör Mikrobiyomunun Araştırılması (BAP)
5. Kinürenin yolağı ve NAD'ın glioblastoma patogenezindeki rolünün in vitro olarak araştırılması (BAP)
   

Contact Info:

E-mail: mhatiboglu@bezmialem.edu.tr