Research
Several mechanisms exist in the brain to detect and respond to disruptions in the balance between satiety and hunger. However, it is possible for these mechanisms to be impaired, which in turn may lead to various disorders and abnormal behaviors, such as binge eating. Binge eating is defined as eating much more than one can consume in a short period of time due to a satiety deficit. To elucidate the underlying neuronal and molecular mechanisms that trigger binge eating, our lab utilizes wide range of cutting-edge technologies. By using recombinase driver mice and recombinase-dependent AAVs that express a variety of genetically encoded tools, the major goals of Caglarlab are to:
1-) Map neuronal connectivity and establish wiring diagrams
2-) Control the firing rate of neurons in vivo to determine their functions in the regulation of binge eating
3-) Obtain insights into the response of neurons in vivo to binge eating
Thus, the accumulation of knowledge in our lab will provide new principals for appetite regulation to develop novel therapeutic agents to combat binge eating and its related disorders.
Selected Publications
In collaboration with researchers at Harvard, Princeton, Yale, and The Rockefeller University, Dr. Caglar has published work in high impact journals such as Cell, Neuron, American Journal of Human Genetics, PNAS, among others.
- Caglar, C., & Friedman, J. (2021). Restriction of food intake by PPP1R17-expressing neurons in the DMH. Proceedings of the National Academy of Sciences of the United States of America, 118(13), e2100194118. https://doi.org/10.1073/pnas.2100194118
- Schneeberger, M., Tan, K., Nectow, A. R., Parolari, L., Caglar, C., Azevedo, E., Li, Z., Domingos, A., & Friedman, J. M. (2018). Functional analysis reveals differential effects of glutamate and MCH neuropeptide in MCH neurons. Molecular Metabolism, 13, 83–89. https://doi.org/10.1016/j.molmet.2018.05.001
- Erson-Omay, E. Z., Çağlayan, A. O., Schultz, N., Weinhold, N., Omay, S. B., Özduman, K., Köksal, Y., Li, J., Harmancı, A. S., Clark, V., Carrion-Grant, G., Baranoski, J., Çağlar, C., Barak, T., Coşkun, S., Baran, B., Köse, D., Sun, J., Bakırcıoğlu, M., ... Günel, M. (2015). Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro-Oncology, 17(10), 1356–1364. https://doi.org/10.1093/neuonc/nov052
- Schaffer, A. E., Eggens, V. R. C., Çağlayan, A. O., Reuter, M. S., Scott, E., Coufal, N. G., Silhavy, J. L., Xue, Y., Kayserili, H., Yasuno, K., Rosti, R. O., Abdellateef, M., Caglar, C., Kasher, P. R., Cazemier, J. L., Weterman, M. A., Cantagrel, V., Cai, N., Zweier, C., ... Gleeson, J. G. (2014). CLP1 founder mutation links tRNA splicing and maturation to cerebellar development and neurodegeneration. Cell, 157(3), 651–663. https://doi.org/10.1016/j.cell.2014.03.049
- Mishra-Gorur, K., Çağlayan, A. O., Schaffer, A. E., Chabu, C., Henegariu, O., Vonhoff, F., Akgümüş, G. T., Nishimura, S., Han, W., Tu, S., Baran, B., Gümüş, H., Dilber, C., Zaki, M. S., Hossni, H. A. A., Rivière, J. B., Kayserili, H., Spencer, E. G., Rosti, R. Ö., ... Günel, M. (2014). Mutations in KATNB1 cause complex cerebral malformations by disrupting asymmetrically dividing neural progenitors. Neuron, 84(6), 1226–1239. https://doi.org/10.1016/j.neuron.2014.11.014
- Jerber, J., Zaki, M. S., Al-Aama, J. Y., Rosti, R. O., Ben-Omran, T., Dikoglu, E., Silhavy, J. L., Caglar, C., Musaev, D., Albrecht, B., Campbell, K. P., Willer, T., Almuriekhi, M., Çağlayan, A. O., Vajsar, J., Bilguvar, K., Ogur, G., Abou Jamra, R., Günel, M., & Gleeson, J. G. (2016). Biallelic mutations in TMTC3, encoding a transmembrane and TPR-containing protein, lead to cobblestone lissencephaly. The American Journal of Human Genetics, 99(5), 1181–1189. https://doi.org/10.1016/j.ajhg.2016.09.021
Çağlar Lab Projects
- Caner Çağlar Yüksek Kalorili Diyet İndüklü Obezite ile DMHPpp1r17 Nöronları ve Bu Nöronlardaki Nitrik Oksit Sinyal Yolağı Arasındaki İlişkinin İncelenmesi In Revision
- Caner Çağlar Dmhpdyn Nöronlarının Agresyon Üzerinde Etkisinin Incelenmesi In Revision
- Caner Çağlar DMHPPP1R17 Nöronları, Anksiyete ve Tıkınırcasına Yemek Yeme Arasındaki İlişkinin İncelenmesi Ongoing
- Caner Çağlar Obezite ile Ilişkilendirilmiş Steap1b, Kcnq5 ve Ucp1 Genlerinin Hastalık Patogenezindeki Rollerinin Araştırılması ve Moleküler Karakterizasyonu Ongoing
