Mustafa Aziz Hatiboglu
Dr. Mustafa Aziz Hatiboglu, is currently Professor and Chair in the Department of Neurosurgery at Bezmialem Vakif University Medical School in İstanbul. He completed his medical school in 2001 at the Ankara University School of Medicine. He had his neurosurgical training from the, İstanbul Okmeydani Training and Research Hospital, Turkey. Dr. Hatiboglu further studied clinical and basic science research on glioma and brain metastasis as a post-doctoral research fellow between 2007 and 2010 in the department of Neurosurgery at the University of Texas MD Anderson Cancer Center, Houston, TX. He also worked as a clinical fellow on Neurosurgical Oncology for one year at MD Anderson between 2010 and 2011. During this period, he received Journal of Neuro-Oncology Award in 2008 and National Brain Tumor Society Mahaley Clinical Research Award in 2010. Dr. Hatiboglu started his academic carrier in Türkiye as an Assistant Professor in the Department of Neurosurgery at Bezmialem Vakif University in 2014 and is currently working as Professor in the same department. He also established his “Brain tumor research lab" at BILSAB. His clinical and research interest is in central nervous system malignancies particularly gliomas and brain metastasis. He, as a clinician and a researcher, can establish a bridge between clinical problems and address this problem with basic science and translational research. His research area includes chemo- and radio-resistance mechanisms in brain cancers particularly in glioma cancer stem cells; optimizing radiation dosing schedule and combinational treatments; nanoparticle use in diagnosis and treatment; mRNA vaccination in glioblastoma; liquid biopsy; brain cancer microbiome and metabolomics.
Research Area: Glioma and brain metastasis, Identification of biomarkers in brain tumors, Liquid biopsy, brain cancer microbiome and metabolomics, Therapeutics, Nanoparticles Based Drug/Vaccine delivery against glioblastoma,
Field of expertise
Neurosurgery, Neuro-oncology, Translational research
Scientific Impact
Brain cancers - glioblastoma in particular - are very challenging to treat, and there has been no complete cure and no first-hand diagnosis of this fatal brain disease. One of the key areas that we, as a group, are emphasizing is to look for suitable biomarkers for diagnostic and therapeutic purposes by exploring and uncovering molecular and genetic uniqueness via multi-omics studies. Another aspect of our research is to follow a more patient-centered and translational approach that can help us devise new strategies in diagnosing and treating glioblastoma.
Ongoing work
Our team is working on multiple aspects of glioblastoma and brain metastasis diagnostics and therapeutics. Some of our priority areas are the identification of prognostic markers through liquid biopsy, the role of gut microbiota and metabolomic properties in glioblastoma, and the use of nanoparticles in the delivery of vaccines and drugs across the blood-brain barrier. Also, we perform multi-omics studies including clinical / radiological data, transcriptomics, and metabolomics to better understand biology and behavior of brain tumors.
About the team
Currently, the Brain Tumor Research Laboratory/Molecular Biology Laboratory has one post-doctoral fellow, one PhD Scholar, one Master Student and one intern.
Dr. Mohd Haseeb, Postdoc
Dr. Mohd Haseeb completed his undergraduate and postgraduate degrees in Biotechnology from Integral University, Lucknow India. He obtained his PhD in nano-biotechnology from National College (Autonomous), Bharathidasan University, Tamilnadu, India in 2020. He has served as an assistant professor of biochemistry and Immunology between 2011-2016 and from 2020-2023 at various academic institutions and universities across northern India. His area of specialization includes nanoparticle synthesis, the development of nanoparticle-based drug delivery systems against cancer, and multi-drug-resistant microbes. He is currently working on developing novel fluorescent carbon dots as theragnostic agents against glioblastoma and developing new diagnostic approaches against glial tumors.
Berrin Saraçoğlu, Phd Student/ Biotechnology
Hatice Kırkıç, technician/ graduate student at Biotechnology
Bahar Ergün, Volunteer/ undergraduate student Molecular Biology
“I am highly grateful to management and especially to Prof. (Dr.) Mustafa Aziz for this wonderful opportunity to work under his esteemed mentorship and guidance. BILSAB is equipped with a modern state-of-the-art research facility to support high-quality research. It harbors research experts and professionals from globally accredited institutions, conducting research in various areas of life sciences and biotechnology. It provides a great platform to experts as well as budding researchers, offering research support and internships for UG & PG students, Ph.D. and Post-doctoral positions. I would highly recommend BILSAB because of its research facilities, support, peaceful work environment, and standard work ethics."
Dr. Mohd Haseeb, Post-Doc at BILSAB.
Lab alumni:
Dr. Imran Khan
Dr. Sadaf Mahfooz
Mohamed Aly, Asist. Prof. The British University in Egypt
Büşra Karaçam
Burçe Elbasan
Öykü Dağdeviren
Zeynep Kartal
Yusuf Çiçek, MD
Berre Toraman, MD
Hasiba Karimi, MD
İclal Meriç
Alumni feedback
A fruitful and memorable postdoctoral journey at Bezmialem Vakıf University has been a truly transformative chapter in my academic and personal life. The vibrant research environment, the warmth and generosity of my colleagues and mentors, and the spirit of scientific collaboration at the Beykoz Institute of Life Sciences and Biotechnology (BILSAB) have inspired me deeply and enriched my research endeavors. I would like to extend my heartfelt gratitude to Professor Mustafa Aziz Hatiboglu, whose visionary guidance, unwavering support, and encouragement were essential to every step of my growth. Professor Aziz's mentorship not only advanced my scientific journey but also instilled in me a passion for discovery, integrity, and perseverance. The opportunities to lead innovative projects, mentor students, and learn from a diverse, talented team have shaped my scientific perspective and fostered lifelong bonds. I carry forward cherished memories and immense appreciation for Bezmialem's commitment to research excellence, and I am honored to remain part of this distinguished alumni family, always grateful for the friendships and inspiration I found at Bezmialem.
Dr. Imran Khan, Ph.D,
Post-Doctoral Research Associate
Department of Radiation Oncology, Mayo Clinic Phoenix Arizona, USA
Reflecting on my time as a postdoctoral researcher at Bezmialem, I am filled with gratitude for the rich academic and scientific environment that shaped my growth. Being surrounded by passionate scholars and dedicated mentors provided countless opportunities to expand my knowledge and skill set. This unique atmosphere encouraged both innovation and persistence in every aspect of my research. I especially want to express my heartfelt thanks to my supervisor, Professor Aziz, whose guidance and encouragement were pivotal throughout my journey. His mentorship not only advanced my research skills but also inspired me on a personal level.I am deeply appreciative of the support received from faculty and peers, whose mentorship broadened my perspective and fostered a strong sense of community. As I move forward, I carry fond memories and the highest respect for Bezmialem's scholarly environment. I look forward to staying engaged with the alumni network and contributing to our shared vision for impactful research and innovation.
Dr. Sadaf Mahfooz, Ph.D
Post-Doctoral Researcher,
Department of Radiation Oncology,
Mayo Clinic Phoenix Arizona, USA
“I learned a lot while working with Dr. Aziz. He helped me grow both experimentally and theoretically, while also giving me valuable insights into clinical approaches. I will always be grateful for the opportunities he provided in Neurolab"
Burçe Elbasan,
Research Associate at Immunotherapeutics
Ongoing Grants
Glioma kaynaklı eksozom ve serbest-DNA'ların normal astrositleri tümöre dönüştürme potansiyellerinin incelenmesi Liquid Biopsy, Carcinogenesis Imran Khan, Büşra Karaçam, Burçe Elbasan, Sadaf Mahfooz, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2020 ongoing
Gliomalı Hastalarda Tümör Mikrobiyomunun Araştırılması Tumor Microbiome Imran Khan, Büşra Karaçam, Sadaf Mahfooz Burçe Elbasan, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2020 Ongoing
Identification of novel therapeutic miRNA candidate for targeting the NOTCH signaling pathways in temozolomide resistant glioblastoma cells Chemoresistance Imran Khan, Sadaf Mahfooz, Büşra Karaçam, Burçe Elbasan, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2021 Ongoing
Gliomalarda kök hücre ve primer tümör hücrelerinin elde edilmesi ve tedaviye direnç mekanizmalarının araştırılması Primary Cell, Cancer Stem-cell Imran Khan, Büşra Karaçam, Sadaf Mahfooz, Öykü Dağdeviren, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2021 Ongoing
Beyin tümörlerinin metabolik profillerinin incelenmesi Metabolomics Imran Khan, Büşra Karaçam, Sadaf Mahfooz, Öykü Dağdeviren, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2021 Ongoing
NOTCH1 genini hedef alan teröpatik mikroRNA'ların Temozolomide dirençli glioblastoma hücre hattında araştırılması Chemoresistance Büşra Karaçam, Öykü Dağdeviren, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2022 Ongoing
Glioblastoma'da Kemoterapiye Dirençten Sorumlu STAT3 İlişkili MikroRNA'ların Araştırılması Chemoresistance Refiye İclal Meriç, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2023 Ongoing
Fare Intraserebral Melanoma Metastaz Modelinde Bağırsak Mikrobiyatasının Tümör Gelişimine Etkisinin İncelenmesi Microbiome Sena Nur Söyler, Mustafa Aziz Hatiboğlu Prof. Dr. Mustafa Aziz Hatiboğlu 2023 Ongoing
Fare Intraserebral Melanoma Metastaz Modelinde Bifidobacterium ve Anti- PD-1 Kombinasyon Tedavisinin Değerlendirilmesi- 1 Microbiome Mustafa Aziz Hatiboğlu, Mehmet Hakan Seyithanoğlu, Kerime Akdur, Büşra Karaçam, Öykü Dağdeviren, Sena Nur Söyler Prof. Dr. Mustafa Aziz Hatiboğlu 2023 Ongoing
Fare Intraserebral Melanoma Metastaz Modelinde Bifidobacterium ve Anti- PD-1 Kombinasyon Tedavisinin Değerlendirilmesi- 2 Microbiome Mehmet Hakan Seyithanoğlu, Mustafa Aziz Hatiboğlu, Kerime Akdur, Büşra Karaçam, Öykü Dağdeviren, Sena Nur Söyler Prof.Dr.Mustafa Aziz Hatiboğlu 2023 Ongoing
Glioblastoma'da NOTCH Sinyal Yolağı İlişkili Kodlamayan RNA'ların Araştırılması ve Potansiyel Tedavilerin Geliştirilmesi Chemoresistance Büşra Karaçam, Mustafa Aziz Hatiboğlu Büşra Karaçam 2023 Ongoing
Glioblastoma'da Lipozomal mRNA Aşı Tedavisi: Mezenkimal Kök Hücreleri Aracılığı İle Anti-Tümör Ripk-3 mRNA Yüklü Lipozomların Taşınması
LNP based Vaccine delivery Prof. Dr. Mustafa Aziz Hatiboğlu, Berrin Saraçoğlu, Prof. Dr. Mustafa Aziz Hatiboğlu 2022 Ongoing
Green Synthesis of Carbon Quantum Dots for Improved Therapeutic Potential of Temozolomide (TMZ) with Thymoquinone (TQ) Against Glioblastoma Carbon Dots -based drug delivery Mohd Haseeb, Mustafa Aziz Hatiboğlu, Kerime Akdur, Dr. Mohd Haseeb 2024 Ongoing
Theranostics Carbon quantum dots for in vivo tumor imaging and therapy in Glioblastoma Carbon Dots -based bio-imaging and drug delivery Mohd Haseeb, Mustafa Aziz Hatiboğlu, Kerime Akdur, Dr. Mohd Haseeb 2025 Ongoing
Selected Publications
Brain metastasis from an adenoid cystic carcinoma of the bartholin gland. Case report. Hatiboglu MA, Cosar M, Iplikcioglu AC, Ozcan D. J Neurosurg 2005 Mar; 102(3): 543-6.
Epidural spinal cavernous hemangioma: Case report. Hatiboglu MA, Iplikcioglu AC, Ozcan D. Neurol Med Chir (Tokyo) 2006 Sep;46(9):455-8.
Is dexmedetomidine a useful adjunct for awake intubation in retropharyngeal neurofibromatosis? Turgut N, Turkmen A, Altan A, Ali A, Hatiboglu MA, Bek S. The Internet Journal of Anesthesiology 2007 Vol. 12, No: 2.
Extracranial aneurysm of posterior inferior cerebellar artey. Gokduman C, Iplikcioglu C, Hatiboglu MA. J Clin Neurosci 2007 Dec;14(12):1220-2.
Sex steroid and epidermal growth factor profile of giant meningiomas associated with pregnancy. Hatiboglu MA, Cosar M, Iplikcioglu AC, Ozcan D. Surg Neurol 2008 Apr; 69(4):356-62.
Evaluating the factors affecting cerebral vasospasm in patients after aneurysmal subarachnoid haemorrhage. Hatiboglu MA, Bikmaz K, Iplikcioglu AC, Turgut N. Acta Neurochir Suppl 2008, 104: 363-365.
Asymptomatic cerebellopontine angle and lateral ventricle metastases from renal cell carcinoma: case report and literature review. Hassaneen W, Hatiboglu MA, Chowdhury S, Sawaya R. J Neurooncol 2009 Jan;91(1):101-6.
Comparative risk of leptomeningeal dissemination of cancer after surgery or stereotactic radiosurgery for a single supratentorial solid tumor metastasis. Suki D, Hatiboglu MA, Patel AJ, Weinberg JS, Groves MD, Mahajan A, Sawaya R. Neurosurgery 2009 Apr;64(4):664-74.
Impact of intraoperative high-field magnetic resonance imaging-guidance on glioma surgery: A prospective volumetric analysis. Hatiboglu MA, Weinberg JS, Suki D, Rao G, Prabhu S, Shah K, Jackson E , Sawaya R. Neurosurgery 2009 Jun;64(6):1073-81.
A predictive tool by fuzzy logic for outcome of patients with intracranial aneurysm. Hatiboglu MA, Altunkaynak A, Ozger M, Iplikcioglu AC, Cosar M, Turgut N. Expert Systems with Applications 2010 March 37(2):1043-1049.
Factors influencing the risk of local recurrence after resection of a single brain metastasis. Patel AJ, Suki D, Hatiboglu MA, Shi W, Wildrick DM, Sawaya R. J Neurosurg. 2010 Aug;113(2):181-9.
Utilization of intraoperative cortical mapping in glioma surgery with intraoperative magnetic resonance imaging. Hatiboglu MA, Prabhu S, Suki D, Tummala S, Sawaya R, Weinberg J. Stereotact Funct Neurosurg. 2010;88(6):345-52.
Immune therapeutic targeting of glioma cancer stem cells. Hatiboglu MA, Wei J, Wu AS, Heimberger A. Target Oncol. 2010;5(3):217-27.
Outcomes and Prognostic Factors for Patients with Brainstem Metastasis Undergoing Stereotactic Radiosurgery. Hatiboglu MA, Chang EL, Suki D, Sawaya R, Weinberg J. Neurosurgery. 2011; Oct;69(4):796-806
Glioma-associated Cytomegalovirus Mediates Subversion of the Monocyte Lineage to a Tumor Propagating Phenotype. Dziurzynski K, Wei J, Qiao W, Hatiboglu MA, Kong LY, Wu A, Gumin J, Henry V, Wang Y, Cahill D, Levine N, Prabhu S, Rao G, Sawaya R, Heimberger AB. Clin Cancer Res. 2011 Jul 15;17(14):4642-4649
The tumor microenvironment influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. Hatiboglu MA, Kong LY, Wei J, Wang Y, McEnery KA, Fuller GN, Qiao W, Davies MA, Priebe W, Heimberger AB. Int J Cancer. 2012; Jul 1;131(1):8-17
The role of surgical resection in patients with brain metastases. Hatiboglu MA, Wildrick D, Sawaya R. Ecancermedicalscience. 2013 Apr 18;7:308
Factors affecting survival in 267 consecutive patients undergoing surgery for spinal metastasis from renal cell carcinoma. Tatsui C, Suki D, Rao G, Salaskar A, Kim S, Hatiboglu MA, Gokaslan ZL, McCutcheon IE. J Neurosurg: Spine. 2014 Jan;20(1):108-16.
Is progesteron receptor status really a prognostic factor for intracranial meningiomas? Iplikcioglu AC, Hatiboglu MA, Ozek E, Ozcan D. Clin Neurol Neurosurg. 2014 Sep;124:119-22.
Impact of surgical methodology on the complication rate and functional outcome of patients with a single brain metastasis. Patel AJ, Suki D, Hatiboglu MA, Rao VY, Fox BD, Sawaya R. J Neurosurg. 2015 May;122(5):1132-43.
Treatment of high number of brain metastases with Gamma Knife radiosurgery: a review. Hatiboglu MA, Tuzgen S, Akdur K, Chang EL. Acta Neurochir (Wien) 2016. 2016 Apr;158(4):625-34.
Evaluation of Auditory Pathways Using DTI in Patients Treated with Gamma Knife Radiosurgery for Acoustic Neuroma: A Preliminary Report. Kurtcan S, Hatiboglu MA, Alkan A, Toprak H, Seyithanoglu MH, Aralasmak A, Atasoy B, Uysal O. Clin Neuroradiol. 2017 Mar 3. doi: 10.1007/s00062-017-0572-1. [Epub ahead of print].
Evaluating Critical Brain Radiation Doses in the Treatment of Multiple Brain Lesions with Gamma Knife Radiosurgery. Hatiboglu MA, Akdur K. Stereotact Funct Neurosurg. 2017;95(4):268-278.
Thymoquinone Induces Apoptosis in B16-F10 Melanoma Cell Through Inhibition of p-STAT3 and Inhibits Tumor Growth in a Murine Intracerebral Melanoma Model. Hatiboglu MA, Kocyigit A, Guler EM, Akdur K, Nalli A, Karatas E, Tuzgen S. World Neurosurg. 2018 Jun;114:e182-e190. doi: 10.1016/j.wneu.2018.02.136.
BRAF V600E mutation and BRAF VE1 immunoexpression profiles in different types of glioblastoma. Tosuner Z, Geçer MÖ, Hatiboğlu MA, Abdallah A, Turna S. Oncol Lett. 2018 Aug;16(2):2402-2408. doi: 10.3892/ol.2018.8919.
Tumor dissemination along biopsy trajectory in brain metastasis. Hatiboglu MA. Jpn J Clin Oncol. 2018 Sep 1;48(9):864-865. doi: 10.1093/jjco/hyy103.
Neurosurgical management of patients with brain metastasis. Hatiboglu MA, Akdur K, Sawaya R. Neurosurg Rev. 2018 Jul 29. doi: 10.1007/s10143-018-1013-6. [Epub ahead of print] Review.
Toxicity of Radiosurgery for Brainstem Metastases. Patel A, Dong T, Ansari S, Cohen-Gadol A, Watson GA, Moraes FY, Nakamura M, Murovic J, Chang SD, Hatiboglu MA, Chung C, Miller JC, Lautenschlaeger T. World Neurosurg. 2018 Nov;119:e757-e764. doi: 10.1016/j.wneu.2018.07.263.
A rare case of sclerosing meningioma with immunohistochemical features. Cömert D, Tosuner Z, Hatiboglu MA. Br J Neurosurg. 2019 Jan 25:1-2. doi: 10.1080/02688697.2018.1556780.
The correlation between phosphorylated Histone H3 (PHH3) and p-STAT3 in Meningiomas. Ozek E, Akdag H, Tosuner Z, Abdallah A, Hatiboglu MA. Clin Neurol Neurosurg. 2019 Mar;178:46-50. doi: 10.1016/j.clineuro.2019.01.016. Epub 2019 Jan 25.
Effects of Intrathecal Verapamil on Cerebral Vasospasm in Experimental Rat Study. Akkaya E, Evran Ş, Çalış F, Çevik S, Hanımoğlu H, Seyithanoğlu MH, Katar S, Karataş E, Koçyiğit A, Sağlam MY, Hatiboğlu MA, Kaynar MY. World Neurosurg. 2019 Jul;127:e1104-e1111. doi: 10.1016/j.wneu.2019.04.050
Thymoquinone Enhances the Effect of Gamma Knife in B16-F10 Melanoma Through Inhibition of Phosphorylated STAT3. Hatiboglu MA, Kocyigit A, Guler EM, Akdur K, Khan I, Nalli A, Karatas E, Tuzgen S. World Neurosurg. 2019 May 2. pii: S1878-8750(19)31201- doi: 10.1016/j.wneu.2019.04.205.
The efficacy of gamma knife radiosurgery in patients with trigeminal neuralgia: The initial experience of the Bezmialem Vakif University. Akdag H, Comert D, Akdur K, Sakarcan A, Seyithanoglu H, Hatiboglu MA. Neurol India. 2019 Mar-Apr;67(2):476-480. doi: 10.4103/0028-3886.258009.
Glioblastoma Stem Cells and Comparison of Isolation Methods. Dundar TT, Hatiboglu MA, Ergul Z, Seyithanoglu MH, Sozen E, Tuzgen S, Kaynar MY, Karaoz E. J Clin Med Res. 2019 Jun;11(6):415-421. doi: 10.14740/jocmr3781.
Gamma knife radiosurgery compared to whole brain radiation therapy enhances immunity via immunoregulatory molecules in patients with metastatic brain tumours. Hatiboglu MA, Kocyigit A, Guler EM, Nalli A, Akdur K, Sakarcan A, Ozek E, Uysal O, Mayadagli A. Br J Neurosurg. 2019 Jul 18:1-7. doi: 10.1080/02688697.2019.1642445.
Pituitary carcinomas: Rare and challenging. Sinclair, G., Olsson, M., Benmakhlouf, H., Al-saffar, Y., Johnstone, P., Hatiboglu, M. A., & Shamikh, A. Surg Neurol Int. 2019 Aug 9. doi: 10.25259/SNI_112_2019
A challenging case of concurrent multiple sclerosis and anaplastic astrocytoma. Sinclair, G., Al-saffar, Y., Johnstone, P., Hatiboglu, M. A., & Shamikh, A. Surg Neurol Int. 2019 Aug 23. doi: 10.25259/SNI_176_2019
The effect of high mobility group box-1 protein on cerebral edema, blood-brain barrier, oxidative stress and apoptosis in an experimental traumatic brain injury model. Evran, S., Calis, F., Akkaya, E., Baran, O., Cevik, S., Katar, S., Gurel Gurevin, E., Hanimoglu, H., Hatiboglu, M. A., Armut, E. I., Karatas, E., Kocyigit A., Kaynar, M. Y. Brain Res Bull . 2020 Jan 154:68-80. doi: 10.1016/j.brainresbull.2019.10.013
AnvirzelTM regulates cell death through inhibiting GSK-3 activity in human U87 glioma cells. Terzioglu-Usak, S., Nalli, A., Elibol, B., Ozek, E., & Hatiboglu, M. A. Neurol Res. 2020 Jan;42(1):68-75. doi: 10.1080/01616412.2019.1709744.
Herbal Medicine for Glioblastoma: Current and Future Prospects. Khan, I., Mahfooz, S., & Hatiboglu, M. A. Med Chem. 2020 Jan 29. doi: 10.2174/1573406416666200130100833.
Adaptive radiosurgery based on two simultaneous dose prescriptions in the management of large renal cell carcinoma brain metastases in critical areas: Towards customization. Georges Sinclair, M. Stenman, H. Benmakhlouf, P. Johnstone, P. Wersäll, M. Lindskog, M. A. Hatiboglu, U. Harmenberg. SNI. 2020 February, 11. doi:10.25259/SNI_275_2019
Integrating navigated transcranial magnetic stimulation motor mapping in hypofractionated and single-dose gamma knife radiosurgery: A two-patient case series and a review of literature. Islam M., Cooray G., Benmakhlouf H., Hatiboglu M., Sinclair G. SNI. 2020 February. doi:10.25259/SNI_406_2019
Can COVID-19 induce glioma tumorogenesis through binding cell receptors? Khan, I., Hatiboglu, M.A. Med Hypotheses, 2020 June 19; 144: 110009. doi: 10.1016/j.mehy.2020.110009
Coronavirus pandemic: how is neurosurgical-oncology practice affected? Hatiboglu, M.A., Sinclair, G. Br J Neurosurg, 2020 Jun 02, 1-3. doi: 10.1080/02688697.2020.1773398
Metastatic renal cell carcinoma to the brain: optimizing patient selection for gamma knife radiosurgery. Stenman, M. , Benmakhlouf, H. , Wersäll P. , Johnstone P. , Hatiboglu M. A. , Mayer-da-Silva J. , Harmenberg U. , Lindskog M. , & Sinclair G. Acta Neurochir, 2020 September. doi: 10.1007/s00701-020-04537-w
Thymoquinone ameliorates delayed cerebral injury and cerebral vasospasm secondary to experimental subarachnoid haemorrhage. Akkaya, E., Evran, Ş., Çalış, F., Çevik, S., Katar, S., Karataş, E. Hatiboglu M. A.,... & Kaynar, M. Y. Neurologia i Neurochirurgia Polska, 2020 Nov doi: 10.5603/PJNNS.a2020.0090
Targeting Glioblastoma: The Current State of Different Therapeutic Approaches. Khan, I., Mahfooz, S., Elbasan, E. B., Karacam, B., Oztanir, M. N., & Hatiboglu, M. A. Curr Neuropharmacol, 2021 Jan 13. doi: 10.2174/1570159X19666210113152108.
Investigation of cellular effects of thymoquinone on glioma cell. Guler, E. M., Sisman, B. H., Kocyigit, A., & Hatiboglu, M. A. Toxicol Rep, 2021 Jan 4;8:162-170. doi: 10.1016/j.toxrep.2020.12.026
The Effectiveness of Diffusion Tensor Imaging in Determining Radiological Response after Radiosurgery in Patients with Vestibular Schwannoma. Current Medical Imaging. Cesme, D. H., Alkan, A., Sari, L., Kaya, A., Yurtsever, I., Alkan, G., ... & Hatiboglu, M. A. Curr Med Imaging, 2021 Jan 27. doi: 10.2174/1573405617666210127160848.
Importance of Pre-treatment Fractional Anisotropy Value in Predicting Volumetric Response in Patients with Meningioma Treated with Gamma Knife Radiosurgery. Cesme, D. H., Alkan, A., Sari, L., Yabul, F., Temur, H. O., Aykan, M. E., ... & Hatiboglu, M. A. Curr Med Imaging, 2021 Jan 28. doi: 10.2174/2213335608999210128182047.
Deciphering the Role of Autophagy in Treatment of Resistance Mechanisms in Glioblastoma. Khan, I., Baig, M. H., Mahfooz, S., Rahim, M., Karacam, B., Elbasan, E. B., ... & Hatiboglu, M. A. Int J Mol Sci., 2021 Jan 28;22(3):1318. doi: 10.3390/ijms22031318.
Evaluation of Brainstem Subcortical Auditory Pathways with Diffusion Tensor Imaging After Gamma Knife Radiosurgery in Intracanalicular Vestibular Schwannoma. Cesme, D. H., Alkan, A., Gultekin, M. A., Sari, L., Alkan, G., Seyithanoglu, M. H., & Hatiboglu, M. A. (2021). Medeniyet Medical Journal, 36(1), 7.
Coronavirus pandemic: how is neurosurgical-oncology practice affected?.Hatiboglu, M. A., & Sinclair, G. (2021). British Journal of Neurosurgery, 35(6), 805-807.
Metastatic renal cell carcinoma to the brain: optimizing patient selection for gamma knife radiosurgery. Stenman, M., Benmakhlouf, H., Wersäll P., Johnstone P., Hatiboglu M. A., Mayer-da-Silva, J., Harmenberg, U., Lindskog, M., &Sinclair, G. Acta Neurochir, 2021 February, 163:333–342. doi: 10.1007/s00701-020-04537-w
Diffusion Tensor Imaging Features of the Auditory Pathways in Patients With Vestibular Schwannoma After Gamma Knife Radiosurgery. Cesme, D. H., Alkan, A., Gultekin, M. A., Sari, L., Alkan, G., Kaya, A., ... & Hatiboglu, M. A. Cureus 2021 March 27; 13(3). doi: 10.7759/cureus.14143
Importance of pre-treatment Fractional Anisotropy value in predicting volumetric response in patients with meningioma treated with Gamma Knife Radiosurgery. Cesme DH, Alkan A, Sari L, Yabul F, Temur HO, Aykan ME, Seyithanoglu MH, Hatiboglu MA. (2021) Current Medical Imaging, 17(7), 871.
Glioma cancer stem cells modulating the local tumor immune environment. Frontiers in Molecular Neuroscience, 15.Khan, I., Mahfooz, S., Karacam, B., Elbasan, E. B., Akdur, K., Karimi, H., ... & Hatiboglu, M. A. (2022).
Nanomedicine for glioblastoma: Progress and future prospects. In Seminars in Cancer Biology. Academic Press. Khan, I., Baig, M. H., Mahfooz, S., Imran, M. A., Khan, M. I., Dong, J. J., ... & Hatiboglu, M. A. (2022, June).
'Identification of Genetic Alterations in Rapid Progressive Glioblastoma by Use of Whole Exome Sequencing' Khan, I., . Isik, E.B., Mahfooz, S., Khan, M.A.,* & Hatiboglu, M. A,*, Diagnostics (2023)
Gamma Knife Radiosurgery Modulates micro-RNA Levels in Patients with Brain Metastasis.Khan I, Akdur K, Mahfooz S, Elbasan EB, Sakarcan A, Karacam B, Sinclair G, Selek S, Akbas F, Hatiboglu MA Curr Radiopharm. 2023 Feb 2. doi: 10.2174/1874471016666230202164557
Gamma Knife Radiosurgery Modulates micro-RNA Levels in Patients with Brain Metastasis. Khan I, Akdur K, Mahfooz S, Elbasan EB, Sakarcan A, Karacam B, Sinclair G, Selek S, Akbas F, Hatiboglu MA. Curr Radiopharm. 2023 Feb 2. doi: 10.2174/1874471016666230202164557
Promising outcome of patients with recurrent glioblastoma after Gamma Knife-based hypofractionated radiotherapy. Hatiboglu MA, Akdur K, Sakarcan A, Seyithanoglu MH, Turk HM, Sinclair G, Oztanir MN. Neurochirurgie. 2024 Jan 10:101532. doi: 10.1016/j.neuchi.2024.101532. Epub ahead of print.
Role of cell-free DNA and extracellular vesicles for diagnosis and surveillance in patients with glioma. Karacam, B., Elbasan, E.B., Khan, I., Mahfooz, S., Cavusoglu, M., Cicek, Y., Hatiboglu, M.A., (2024). The Journal of Liquid Biopsy.
Hypofractionated radiation therapy suppresses radioresistance in u87 human glioma cells by inhibiting yap1 and hsp90 proteins Khan I., Mahfooz S., Karacam B., Elbasan E.B., Akdur K., Coban G., Hatiboglu M.A. Curr Radiopharm. 2024 Apr doi:10.2174/0118744710300495240409074900.
Status Quo in the Liposome-Based Therapeutic Strategies Against Glioblastoma: “Targeting the Tumor and Tumor Microenvironment" Haseeb, M., Khan, I., Kartal, Z., Mahfooz, S., & Hatiboglu, M. A. (2024). International Journal of Molecular Sciences, 25(20), 11271. https://doi.org/10.3390/ijms252011271
Liquid biopsy for CNS lymphoma: CSF exosomes and CSF exosomal miR-15a, miR-21, miR-155, miR-210, and miR-19b are promising biomarkers for diagnosis. Hatiboglu MA, Karacam B, Khan I, Akdur K, Elbasan EB, Mahfooz S, Seyithanoglu MH, Cetin G, Papaker MG, Oztanir MN. Mol Biol Rep. 2024 Oct 3;51(1):1035.
Carbon Dot Nanoparticle-based Therapeutic Approaches in Major Neurological Disorders Haseeb M, Hatiboglu MA. Mini Rev Med Chem. 2025 Oct 8. doi: 10.2174/0113895575398775250811070903. Epub ahead of print. PMID: 41088943.
Investigating the Role of Biomarkers Using Liquid Biopsy in the Diagnosis of Meningiomas. Karimi H, Mahfooz S, Khan I, Karacam B, Akdur K, Gonen G, Elbasan EB, Hatiboglu MA. Turk Neurosurg. 2025;35(5):783-791.
Management of critically located brain metastases in patients with precluded survival using customised double-dose prescription-based, adaptive accelerated staged radiosurgery: a long-term retrospective analysis. Sinclair G, Martin H, Allison CM, Hatiboglu MA, Speckter H, Fytagoridis A. Radiat Oncol. 2025 Aug 1;20(1):120.
Editorial: Emerging paradigms in understanding cancer metastasis: focus on tumor microenvironment dynamics. Khan I, Farhan M, Khan H and Hatiboglu MA (2025) Front. Mol. Biosci. 12:1736325. doi: 10.3389/fmolb.2025.1736325"
