Mehmet Ziya Doymaz
Dr. Doymaz began his academic and professional journey with a Doctor of Veterinary Medicine (DVM) degree from Ankara University, completed in 1983. Driven by a growing interest in biomedical sciences, he continued his graduate studies at the University of Tennessee, where he earned an MSc in 1988 and subsequently completed his PhD in 1991.
Following his doctoral work, he pursued postdoctoral training at the Mount Sinai School of Medicine in New York between 1991 and 1992, expanding his expertise in advanced biomedical research.
His career then progressed to a clinical research trajectory, culminating in a prestigious clinical fellowship at the University of California, Los Angeles (UCLA) from 2001 to 2004. This fellowship marked the consolidation of his scientific training with clinical application, positioning him at the intersection of academic research and medical practice.
Research Area: Infectious disease.
Field of expertise
Viral Immunology, viral diagnostics, clinical microbiology, antibiotic resistant bacterial isolates,
Ongoing work
Our laboratory primarily investigates the immunological properties of proteins of Crimean-Congo Hemorrhagic Fever Virus. This virus gained an endemic status in this country and in many countries spanning from China to Kosova where the third of the world population inhabits. Complex life cycle of the virus involving ticks, wild rodents and domestic animals makes the preventive measures almost futile. Consequently, an immunological intervention to the disease and to its agent seem like the most effective mean to curb the spread of infection in the long haul. We are studying both humoral and cellular immune elements against the viral proteins, primarily nucleocapsid and glycoproteins with the forecast that a better understanding of the immunology and immunopathology of the infection will enable us to design better mechanisms to intervene the infectious process. Our laboratory set up is a typical immunology-molecular biology laboratory equipped with the state of the art means including confocal microscopy, FACS and protein purification instrumentations. The availability of animal facilities and other necessary core facilities makes us to address the immunological questions in
in vivo conditions.
About the team
Our team consists of PI, two PhD PhD Students, one postdoc, and two MSc students.
Ayşegül Pirincal Post Doc
Filiz Kaptan MSc Graduate Student
Sercan Keskin PhD Student
Özlem Bakangil PhD Student
Ömür Gözde Demirtaş MSc Student
Projects
'Identification and investigation of antigenicity of Spherical Body Protein 4 (SBP4) of abesia ovis'. TUBITAK 1001, 222O123, Budget 1.332.600 TL, 2023-2026.
Lab alumni
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Elif Karaaslan, PhD Post-Doctoral Fellow at Center for Disease Control and Prevention, Atlanta, GA, U.S.A.
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Sevde Hasanoğlu, MSc Bezmialem Clinical Microbiology Laboratory
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Nesibe Selma Çetin, PhD Medipol University
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Merve Yazıcı, PhD Medipol University
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Burcu Nur Aydın, MSc Medipol University
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Murat Ihlamur Biruni University
Completed grants/projects
'Establishment of the Infrastructure of Institute of Life Sciences and Biotechnology' Funded by Turkish Ministry of Development,
'Development of nanoparticle-based carrier systems containing immunochemotherapeutic agents against visceral leishmaniasis'. Co-investigative Project with Yıldız Technical University Funded by TÜBİTAK 1003,
'Development of virus like particle-based vaccine against SARS-CoV-2' Funded by TUSEB,
'Investigation of antigenic similarities between Hazara virus nucleoprotein and Crimean Congo hemorrhagic fever virus nucleoprotein in terms of cellular response' Funded by Bezmialem Vakıf University Scientific Research Project Unit,
'Generation of Plasmid-Based Virus-Like Particle in Crimean Congo Hemorrhagic Fever Virus'. Bezmialem Vakıf University Scientific Research Project Unit.
'Evaluation of TritonX-100's inactivation effect on Influenza Virus infection'. Bezmialem Vakıf University Scientific Research Project Unit.
'Development of serological diagnostic methods for Crimean-Congo Hemorrhagic Virus'. Funded by TÜBİTAK 1003 Program.
'Analysis of immunological properties non-structural proteins of Crimean-Congo Hemorrhagic Fever Virus'. Funded by TÜBİTAK 1001.
Investigation of lymphoproliferative and Delayed Type Hypersensitivity Responses against Nucleoprotein of Crimean Congo Hemorrhagic Fever Virus Kelkit Strain'. Bezmialem Vakıf University Scientific Research Project Unit.
Immunological Characterization of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein mRNA Product. Bezmialem Vakıf University Scientific Research Project Unit.
Identification of Antigenic Regions in Cellular Th17 Responses to Crimean-Congo Hemorrhagic Fever Virus Nucleoprotein (NP). Bezmialem Vakıf University Scientific Research Project Unit.
Stable Expression of Crimean-Congo Hemorrhagic Fever Virus Kelkit Strain Proteins in Eukaryotic Cells. Bezmialem Vakıf University Scientific Research Project Unit.
Selected Publications
Cellular immunity to nucleoproteins (NP) of Crimean-Congo hemorrhagic fever virüs (CCHFV) and Hazara Virus (HAZV) M. Kalkan-Yazıcı, N. S. Çetin, E. Karaaslan, M. Z. Doymaz Medical Microbiology and Immunology, cilt 213, sa.1, 2024 (SCI- Expanded)
The Role of Nucleocapsid Protein (NP) in the Immunology of Crimean Congo Hemorrhagic Fever Virus (CCHFV) (Review) A. Pirinçal, M. Z. Doymaz Viruses https://doi.org/10.3390/v16101547 2024
Kalkan-Yazıcı M, Karaaslan E, Çetin NS, Hasanoğlu S, Güney F, Zeybek Ü, Doymaz MZ. 2021. Cross-Reactive anti-Nucleocapsid Protein Immunity against Crimean-Congo Hemorrhagic Fever Virus and Hazara Virus in Multiple Species. J Virol. 2021 Jan 13:JVI.02156-20. doi: 10.1128/JVI.02156-20. Online ahead of print.
KalkanYazıcı, M., Koc, M. M., Cetin, N. S., Karaaslan, E., Okay, G., Durdu, B., Sumbul, B., Doymaz, M. Z., 2020. Discordance between serum neutralizing antibody (NAb) titers and the recovery from Coronavirus Disease-2019 (COVID-19). J. Immun. 2020 Sep 25:ji2000840. doi: 10.4049/jimmunol.2000840.
Sumbul B, Doymaz MZ. A Current Microbiological Picture of Mycobacterium Isolates from Istanbul, Turkey. Pol J Microbiol. 2020;69(2):1-7. doi: 10.33073/pjm-2020-021.
Doymaz MZ, Karaaslan E. 2019. Comparison of antibacterial activities of polymyxin B and colistin against multidrug resistant Gram negative bacteria. Infect Dis (Lond). 2019 Sep;51(9):676-682. doi: 10.1080/23744235.
